报告人：刘贤德博士报告题目：免疫检查点PD-L1的降解与调节报告时间：12月18日（周日）上午10:00报告地点：重点实验室103室主办单位：江苏省药用植物生物技术重点实验室、生命科学学院、科技处报告人简介：Jiangsu Normal University, BS7/1997Biological SciencesChinese Academy of Sciences, Shanghai, ChinaPHD7/2005Biological SciencesBaylor College of Medicine, Houston, FellowshipPostdoc. Fellowship 9/2005-1/2011 A.Positions and HonorsPositions and Employment2012-presentInstructor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX2011-2012Instructor, Department of Medicine Baylor College of Medicine, Houston, TX2005-2011Postdoctoral Associate, Department of Medicine Baylor College of Medicine, Houston, TX1997-2000Lab Manager, Department of Biology Jiangsu Normal University, Jiangsu, ChinaB.Selected Peer-reviewed Publications1.Liu XD*, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E*, Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis. Oncogene.2015 34:2450-60, PubMed PMID: 24998849; PMCID: 4286517 (*Co-corresponding author)2.Liu XD, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, Ding Z, Bai S, German P, Zhang X, Tamboli P, Rao P, Karam J, Wood C, Matin S, Zurita A, Bex A, Griffioen AW, Tannir N, Sircar K, Jonasch E. Resistance to anti-angiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma. Cancer Immunology Research, 2015 May 26. pii: canimm.0244.2015. PMID: 26014097 3.Liu XD, Ko S, Xu Y, Fattah EA, Xiang Q, Jagannath C, Ishii T, Komatsu M, Eissa NT.Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress.J Biol Chem. 2012, 287(23):19687-98. 4.Liu XD, Mazumdar T, Xu Y, Getzoff ED, Eissa NT. Identification of a flavin mononucleotide module residue critical for activity of inducible nitrite oxide synthase.J Immunol. 2009 183(9):5977-825.Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity.Immunity. 2007, 27(1):135-44. 6.Xu Y, Liu XD, Gong X, Eissa NT. Signaling pathway of autophagy associated with innate immunity.Autophagy. 2008, 4(1):110-2. 7.Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E. Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma.Oncogene. 2015 Sep 14. doi: 10.1038/onc.2015.3438.German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z. Phosphorylation-dependent cleavage regulates Von Hippel Lindau proteostasis and function. Oncogene. 2016, 22: 4973-4980. 9.Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.Cancer Research, 2014 74:3127-36 10.Deeraksa A, Pan J, Sha Y, Liu XD, Eissa NT, Lin SH, Yu-Lee LY. Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis.Oncogene. 2013, 32(24):2973-83. 11.DePavia A, Jonasch E, Liu XD*. Autophagy degrades hypoxia inducible factors.Mol Cell Oncol. 2016 Mar 16;3(2):e1104428. doi: 10.1080/23723556.2015.1104428. (Invited review, *Corresponding author)12.Ho TH, Liu XD*, Huang Y, Warneke CL, Johnson MM, Hoang A, Tamboli P, Wang F,and Jonasch E,The impact of FGFR1 and FRS2 alpha expression on sorafenib treatment inmetastatic renal cell carcinoma, BMC Cancer, 2015 15:304, PubMed PMID: 25900027; PMCID: 4406182 (*Equal contribution)13.Liu XD*, Zhu H, DePavia A, Jonasch E, Dysregulation of HIF2a in renal cell carcinoma. Molecular & Cellular Oncology, 2014 2:2, e965643(Invited review, * Corresponding author)
